Laboratory research direction is the synthesis of lead compounds for structure based drug design, according to the animal various diseases of small molecule database virtual screening, homologous predictive modeling and structure of the unknown target structure, molecular dynamics simulation of the interaction between biological macromolecules and ligands, and using the method of protein crystallography of biological macromolecules is the key the structure analysis. In order to make full use of the traditional Chinese medicine resources in our country, we can search for the new drug lead compounds from five thousand years old Chinese medicine prescriptions, so as to make the search of the new drug lead compounds in an effective and limited range. The emphasis on target, inhibitors or antagonists for Chinese medicine for prevention and treatment of diseases of livestock and poultry YISHION flu related, and Mycobacterium tuberculosis shikimate pathway blocker research, in order to find a better treatment for influenza from Chinese medicine resources.

At the same time, we focus on the research and development of saponins with good pharmacological activity, and accumulated rich experience in the synthesis of natural saponins and the synthesis of carbohydrates.

Saponin is an important natural product and an important component of water solubility. In China, as the largest source of traditional Chinese medicine, more than half of the more than eight thousand kinds of medicinal plants. Natural saponin is low in nature and complex in separation process, which is time-consuming and laborious. Saponins obtained from natural resources are sometimes not very active or toxic, so they are difficult to be developed into new drugs. Compared with saponin, diosgenin is easy to separate, and it is easy to be industrialized. The chemical structure and biological activity of the laboratory system of saponins, using natural saponins out pharmacological activity as nucleus orientation required for the synthesis of saponin, modified and improved and and to study the relationship between structure and activity, so that the development of good curative effect and low side effect with independent intellectual property rights of the original drugs. For example:

1) the development of natural products directory ---20 (S) - ginsenoside Rh2, Trillin, diosgenin and Salidroside

2) the development of pharmaceutical intermediates - the original ginseng glycol, the original ginseng three alcohol, etc.

3) natural animals - bile, etc.